Quantifying the Relationship Between Physical Activity Energy Expenditure and Incident Type 2 Diabetes: A Prospective Cohort Study of Device-Measured Activity in 90,096 Adults
Authors' conclusion
There was a strong linear relationship between PAEE and incident T2D. A difference in PAEE equivalent to an additional daily 20-min brisk walk was associated with 19% lower odds of T2D. The association was broadly similar across population subgroups, supporting physical activity for diabetes prevention in the whole population.
Study context
- Population
- UK Biobank participants without prevalent diabetes; mean 62 years, 57% women2,018 T2D events
- Participants
- 90,096 participants
- Exposure
- Per 5 kJ · kg-1 · day-1 higher accelerometer-derived physical activity energy expenditure (PAEE)
- Outcome
- Incident T2D (hospital episode and mortality data)
- Follow-up
- Up to November 2020
Methodological detailsdevice-measured activity (wrist accelerometer, 7 days), logistic regression, progressively adjusted for demographic, lifestyle factors and BMI
- Device-measured activity (wrist accelerometer, 7 days)
- Logistic regression, progressively adjusted for demographic, lifestyle factors and BMI
Main finding
As reported in the abstract
Odds of incident T2D per 5 kJ · kg-1 · day-1 in PAEE
Lower odds of T2D, without BMI adjustment
19%
95% CI 17–21
Lower odds of T2D, with BMI adjustment
11%
9–13
Observational data: associations, not effects.
Further findings
Subgroups
- Association stronger in men than women and weaker in those with obesity and higher genetic susceptibility to obesity
- No evidence of effect modification by genetic susceptibility to T2D or insulin resistance
Activity intensity
- For a given PAEE, odds of T2D lower with more moderate-to-vigorous activity
Original publication
Quantifying the Relationship Between Physical Activity Energy Expenditure and Incident Type 2 Diabetes: A Prospective Cohort Study of Device-Measured Activity in 90,096 Adults. Diabetes Care. Published 24 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →