Quantifying Bone Strength Deficits in Young Adults Born Extremely Preterm or Extremely Low Birth Weight
Main finding · Height- and weight-adjusted torsional stiffness (ktorsion) at 66% tibiaResult — go to the resultMean difference −180 Nm/deg 95% CI −352 to −8Authors' conclusion
Lower height- and weight-adjusted pQCT-FEM measures in EP/ELBW compared with controls suggest a clinically relevant increase in predicted long-term fracture risk in EP/ELBW survivors, particularly males.
Study context
- Population
- Young adults born in Victoria, Australia, during 1991–1992, assessed at age 25 years with peripheral quantitative computed tomography (pQCT) at 4% and 66% of tibia and radius length
- Participants
- 161 vs 122
- Exposure
- Extremely preterm (EP)/extremely low birth weight (ELBW) survivors vs term-born, normal birth weight controls
- EP/ELBWn = 161
- Controlsn = 122reference
- Outcome
- Height- and weight-adjusted torsional stiffness (ktorsion) at 66% tibia
- Follow-up
- Age 25 years
Methodological detailspQCT-based finite element modeling, adjusted for height and weight
- pQCT-based finite element modeling
- Adjusted for height and weight
Main finding
As reported in the abstract
Mean difference
−180 Nm/deg
95% CI −352 to −8
EP/ELBWvs Controls
mean difference −180 Nm/deg (95% CI −352 to −8)
Observational data: associations, not effects.
Further findings
Unadjusted tibial pQCT-FEM parameters · age 25 years
- Several unadjusted tibial pQCT-FEM parameters were lower in EP/ELBW
Group differences by sex in ktorsion and kbend at 66% tibia · age 25 years
- Evidence for group differences stronger among males than females
- pinteractions <0.05
Adjusted radial models · age 25 years
- Little evidence for group differences
Height and weight · age 25 years
- EP/ELBW shorter than controls; weights similar
Original publication
Quantifying Bone Strength Deficits in Young Adults Born Extremely Preterm or Extremely Low Birth Weight. J Bone Miner Res. Published 7 November 2023. doi:10.
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