Efficacy and Toxicity of Calcitonin Treatment in Children with Cherubism: A Single-Center Cohort Study
Authors' conclusion
Calcitonin treatment seems effective and tolerable in treating actively progressing cherubism in children.
Study context
- Population
- Children with cherubism (three female, six male) during the progressive phase of the disease11 treatment courses
- Participants
- 9 children
- Outcome
- Change in the volume of lesions during calcitonin treatment, assessed for the eight treatment courses with a minimal duration of 6 months
- Follow-up
- During treatment
Methodological detailssingle-centre, 11 treatment courses, mean duration 17.9 months (range <1 to 35, SD 10.8)
- Single-centre
- 11 treatment courses, mean duration 17.9 months (range <1 to 35, SD 10.8)
Main finding
As reported in the abstract
Change in cumulative lesion volume during treatment
- Statistically significant reduction in mean cumulative lesion volume regardless of treatment duration
- Average volume reduction highest in first half year of treatment, with gradual, ongoing reduction thereafter
- 8 treatment courses with ≥6 months duration
Observational data: associations, not effects.
Secondary outcomes
Change in cumulative lesion volume after treatment cessation
- Courses after which cumulative volume increased again but remained smaller than initial volume
- 6 of 7
- 7 treatment courses with follow-up imaging
Safety
- Treatment courses with adverse effects
- 73%
- Grade 3 symptomatic hypocalcemia requiring hospitalization and early treatment termination
- 1
- Most adverse effects mild and low grade
- 11 treatment courses
Original publication
Efficacy and Toxicity of Calcitonin Treatment in Children with Cherubism: A Single-Center Cohort Study. J Bone Miner Res. Published 3 November 2023. doi:10.
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