Proteomic signatures of type 2 diabetes predict the incidence of coronary heart disease
Authors' conclusion
Collectively, our findings unveil the proteomic signatures associated with both T2D and CHD, providing implications for screening and predicting future CHD onset in T2D patients.
Study context
- Population
- UK Biobank participants; 2923 plasma proteins
- Participants
- 53,014 participants
- Outcome
- Shared proteomic signatures of T2D and CHD and prediction of incident CHD in T2D patients
Methodological detailsUK Biobank, mediation analyses, druggability evaluation
- UK Biobank
- Mediation analyses
- Druggability evaluation
Main finding
As reported in the abstract
Proteins associated with T2D
488
Of these, proteins also associated with coronary heart disease (CHD)
125
Shared proteins with causal associations with CHD (incl. PCSK9, NRP1, CD27)
9
Predictive model AUC for future CHD onset in T2D patients
0.819
Observational data: associations, not effects.
Further findings
Druggability evaluation
- Potential therapeutic agents, incl. established antihypertensives and nine novel compounds
- 32
Original publication
Proteomic signatures of type 2 diabetes predict the incidence of coronary heart disease. Cardiovasc Diabetol. Published 14 March 2025. doi:10.
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