Proteins and pathways involved in inflammation are longitudinally associated with total body bone mineral density among primarily Hispanic overweight/obese adolescents and young adults
Authors' conclusion
While there were no significant overlapping longitudinal protein associations between the cohorts, these findings suggest differences in protein regulation at different ages and provide novel insight on longitudinal protein associations with BMD in overweight/obese adolescents and young adults of primarily Hispanic origin, which may inform the development of biomarkers for bone health in youth.
Study context
- Population
- Overweight/obese adolescents (SOLAR; baseline age 8–13, 100% Hispanic) with repeated annual DXA BMD; young adult replication cohort (baseline age 17–22; 62.1% Hispanic)SOLAR cohort
- Participants
- 304 adolescents
- Outcome
- Longitudinal associations of baseline plasma proteins (n = 653, Olink) with total body BMD
- Follow-up
- Repeated annual DXA (average 3.2 visits per participant)
Methodological detailsplasma proteomic analysis, covariate-adjusted linear mixed effect regression, adjusted p value cutoff (p < .00068), replication in young adult cohort
- Plasma proteomic analysis
- Covariate-adjusted linear mixed effect regression
- Adjusted p value cutoff (p < .00068)
- Replication in young adult cohort
Main finding
As reported in the abstract
Protein associations with longitudinal changes in total body BMD
- Proteins associated with longitudinal changes in total body BMD, many involved in inflammatory processes
- 44
- Including osteopontin (SPP1) and MFAP5
- both p < .00068
Observational data: associations, not effects.
Further findings
Replication in young adult cohort (n = 169; 346 overlapping Olink proteins)
- No significant overlapping longitudinal protein associations between the cohorts
Original publication
Proteins and pathways involved in inflammation are longitudinally associated with total body bone mineral density among primarily Hispanic overweight/obese adolescents and young adults. J Bone Miner Res. Published 14 January 2025. doi:10.
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