Prospective Test Performance of Nonfasting Biomarkers to Identify Dysglycemia in Children and Adolescents
Authors' conclusion
HbA1c and nonfasting glucose tests had reasonable longitudinal discrimination identifying adolescents at risk for dysglycemia, but performance depended on outcome definition.
Study context
- Population
- Youth aged 8–17 years with overweight or obesity (BMI ≥85th percentile) without known diabetes
- Participants
- 176 participants
- Outcome
- Glucose-defined dysglycemia (FPG ≥100 mg/dL or 2-h plasma glucose ≥140 mg/dL) or elevated HbA1c (≥5.7%) on two fasting 2-h OGTTs
- Follow-up
- Average of 1.1 years later
Methodological detailslongitudinal
- Longitudinal
Performance
As reported in the abstract
Prediction of glucose-defined dysglycemia · follow-up
| Test or model | AUC |
|---|---|
| Random glucose (RG) | 0.68 (95% CI: 0.55-0.80) |
| 1-h GCT | 0.76 (95% CI: 0.64-0.89) |
| Hemoglobin A1c (HbA1c) | 0.70 (95% CI: 0.56-0.84) |
AUC
Random glucose (RG)0.68 (95% CI: 0.55-0.80)
1-h GCT0.76 (95% CI: 0.64-0.89)
Hemoglobin A1c (HbA1c)0.70 (95% CI: 0.56-0.84)
Further findings
| Outcome | HbA1c | RG |
|---|---|---|
| Prediction of elevated HbA1c · follow-up | ||
| AUC | 0.93 [95% CI: 0.88-0.98] | 0.67 [95% CI: 0.54-0.79] |
Prediction of elevated HbA1c · follow-up
- Baseline HbA1c strong, RG moderate performance
- 1-h GCT, fructosamine (FA) and anhydroglucitol performed poorly
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prospective Test Performance of Nonfasting Biomarkers to Identify Dysglycemia in Children and Adolescents. Horm Res Paediatr. Published 15 November 2022. doi:10.
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