The Risk of Severe Hypoglycemia and Mortality in Patients With Type 2 Diabetes and Discharged With Acute Liver Injury
Main finding · Severe hypoglycemiaResult — go to the resultAdjusted hazard ratio 1.92 CI 1.30–2.85Authors' conclusion
This cohort study demonstrated that patients with T2D and discharged with acute liver injury showed significantly higher risks of severe hypoglycemia and mortality within 90 days and 365 days after discharge than patients discharged with other causes.
Study context
- Population
- Patients with T2D hospitalized 2000–2010, National Health Insurance Research Database of Taiwan
- Exposure
- T2D discharged with acute liver injury vs discharged with other causes
- Outcome
- Severe hypoglycemia and mortality
- Follow-up
- Within 90 days and 365 days after discharge
Methodological detailspopulation-based, multivariable-adjusted Cox proportional hazards models
- Population-based
- Multivariable-adjusted Cox proportional hazards models
Main finding
Severe hypoglycemia · within 90 days after discharge
Adjusted hazard ratio
1.92
CI 1.30–2.85
By group
Acute liver injury
12.28/1,000 person-years
Other causes
5.59/1,000 person-years
Acute liver injuryvs Other causes
aHR 1.92 (CI 1.30–2.85)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Acute liver injury | Other causes | aHR (CI) | |
|---|---|---|---|---|
| Severe hypoglycemia · within 365 days after discharge | 7.35/1,000 person-years | 2.9/1,000 person-years | 1.98 (1.52–2.58) | |
| Mortality · within 90 days after discharge | 82.4/1,000 person-years | 27.54/1,000 person-years | 1.73 (1.46–2.05) | |
| Mortality · within 365 days after discharge | 36.8/1,000 person-years | 9.3/1,000 person-years | 1.94 (1.69–2.24) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Hypoglycemia risk subgroups (acute liver injury)
- No significant interaction for age, CKD and medications; significant interaction for sex
Original publication
The Risk of Severe Hypoglycemia and Mortality in Patients With Type 2 Diabetes and Discharged With Acute Liver Injury. Diabetes Care. Published 15 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →