Trajectories of Cognition and Daily Functioning Before and After Incident Diabetes
Authors' conclusion
Incident diabetes is associated with accelerated cognitive and functional decline after, but not before, the event. We suggest careful monitoring for cognitive and physical dysfunction after a diabetes diagnosis.
Study context
- Population
- Older adults in the English Longitudinal Study of Ageing; mean age 65.0 years, 57.8% women576 incident diabetes
- Participants
- 6,342 adults
- Exposure
- Cognitive and functional trajectories after vs before incident diabetes diagnosis
- Incident diabetesn = 576
- Outcome
- Annual rates of change in global cognition (orientation, memory, executive function) and daily functioning (sum of impaired basic and instrumental activities of daily living)
- Follow-up
- Median 13.3 years
Methodological detailsEnglish Longitudinal Study of Ageing, waves 2–9 (2004-2018)
- English Longitudinal Study of Ageing, waves 2–9 (2004-2018)
Main finding
As reported in the abstract
Annual rate of change after vs before diabetes diagnosis
- Global cognition, accelerated decline after vs before diagnosis: β
- −0.035 SD/year (−0.054 to −0.015) (95% CI)
- Orientation, accelerated decline after vs before diagnosis
- −0.031 SD/year (−0.060 to −0.002) (95% CI)
- Memory, accelerated decline after vs before diagnosis
- −0.016 SD/year (−0.029 to −0.003) (95% CI)
- Executive function, accelerated decline after vs before diagnosis
- −0.027 SD/year (−0.042 to −0.013) (95% CI)
- Daily functioning, accelerated postdiabetes vs prediabetes-diagnosis change
- 0.093 points/year (0.056-0.131) (95% CI)
Observational data: associations, not effects.
Further findings
Rate of decline before diagnosis vs participants without diabetes
- Cognitive and functional decline before diagnosis in future incident diabetes similar to that in participants without diabetes
Acute change at diabetes onset
- No significant acute change observed during onset
Original publication
Trajectories of Cognition and Daily Functioning Before and After Incident Diabetes. Diabetes Care. Published 15 November 2022. doi:10.
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