Prospective Associations of Maternal Cardiometabolic Health With Children Cardiometabolic Health at Ages 3 to 6 Years

J Clin Endocrinol MetabPublished Prospective cohort study

Authors' conclusion

Better MCMH in pregnancy was associated with better CCMH at ages 3∼6 years.

Study context

Population
Mother-child dyads, Shanghai Maternal-Child Pairs Cohort; Maternal cardiometabolic health (MCMH) assessed at mean 27.8 (24–36) weeks' gestation by Life Essential 8; Children CMH (CCMH) at age 3 to 6 by 5 metrics
Participants
1,478 mother-child dyads
Exposure
Maternal cardiometabolic health (MCMH) score in pregnancy and child cardiometabolic health (CCMH) at 3–6 years
Outcome
CCMH score (BMI, physical activity, sleep health, diet quality, nicotine exposure)
Follow-up
Ages 3 to 6 years

Main finding

As reported in the abstract

CCMH score per 10-point increase in MCMH score

Mean (SD) MCMH score during pregnancy

67.07

SD 8.82

Mean (SD) CCMH score

73.80

SD 10.75

β for CCMH score per 10-point higher MCMH score, adjusted (95% CI .22, 1.47)

.85

Observational data: associations, not effects.

Further findings

Subgroups by sex

Similar results in girls but not in boys

Child overweight/obesity with increased MCMH score

RR (95% CI .96, .99)
.98

Child hypertension with increased MCMH score

RR (95% CI .47, .92)
.66

Sensitivity analysis: CCMH by 6 metrics (adding blood pressure), 499 children

Similar results

Original publication

Prospective Associations of Maternal Cardiometabolic Health With Children Cardiometabolic Health at Ages 3 to 6 Years. J Clin Endocrinol Metab. Published 13 June 2024. doi:10.1210/clinem/dgae413

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