Progression of Nodular Thyroid Disease in Familial Adenomatous Polyposis Syndrome: Refined Surveillance Recommendations
Authors' conclusion
Based on the Kaplan-Meier analysis, ongoing longitudinal screening is warranted for patients with FAP as they are prone to thyroid cancer and nodule development overtime even when presenting with a baseline normal US. Additionally, these data demonstrate a slow development of thyroid cancer from a normal US, thus it is reasonable to consider selectively extending the screening interval for this population.
Study context
- Population
- Patients with familial adenomatous polyposis (FAP) undergoing screening thyroid ultrasound (US), 2008–2023; 50% male, median age at first screening 38 years80% longitudinal follow-up
- Participants
- 556 patients
- Outcome
- Disease progression on serial US: development of new nodules and cancer
Methodological detailssingle referral center, Kaplan-Meier analysis
- Single referral center
- Kaplan-Meier analysis
Main finding
As reported in the abstract
Cumulative incidence of initial and subsequent thyroid cancer and of thyroid nodules (Kaplan-Meier) · median follow-up 7 years
- Cumulative incidence of thyroid cancer by 5 years
- 4%
- Cumulative incidence of thyroid cancer by 10 years
- 6%
- Cumulative incidence of thyroid nodules by 5 years
- 40%
- Cumulative incidence of thyroid nodules by 10 years
- 48%
- Diagnosed with thyroid cancer
- 20 patients (3.6%)
- Normal baseline US who developed a nodule over time
- 14%
Observational data: associations, not effects.
Further findings
Nodules at initial screening
- Patients with nodules
- 169 (30%)
Original publication
Progression of Nodular Thyroid Disease in Familial Adenomatous Polyposis Syndrome: Refined Surveillance Recommendations. Endocr Pract. Published 21 May 2024. doi:10.
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