Gestational diabetes & diabetes in pregnancy

Progression from gestational diabetes to type 2 diabetes mellitus: A prospective observational study from a resource constrained country-Pakistan

Diabetes Res Clin PractPublished Prospective observational study

Authors' conclusion

A 43.1 % of the women progressed to T2DM during the study period.

Study context

Population
Women diagnosed with gestational diabetes mellitus (GDM) by OGTT, followed up for at least 03 years; Baqai Institute of Diabetology and Endocrinology (BIDE), Baqai Medical University (BMU) and Dow University of Health Sciences (DUHS), Pakistan, July 2019- September 2023; mean age 33.2 ± 7.2 years, mean BMI 31.3 ± 6.1 kg/m²
Participants
489 women
Outcome
Progression to T2DM after GDM diagnosis
Follow-up
After delivery, at six months, at one year, at two and three years
Methodological detailsmulticentre
  • Multicentre

Main finding

As reported in the abstract

Progression to T2DM · during the study period

Women progressed to T2DM

43.1 %

Observational data: associations, not effects.

Further findings

Timing of progression among those who developed T2DM · within 1 year after GDM diagnosis

Developed T2DM within 1 year after GDM diagnosis
53.8 %

Factors associated with T2DM risk

Hypertension, urinary tract infections and jaundice significantly increased the risk
Insulin treatment during pregnancy reduced the odds of T2DM; advancing age and pregnancy complications increased the risk

Original publication

Progression from gestational diabetes to type 2 diabetes mellitus: A prospective observational study from a resource constrained country-Pakistan. Diabetes Res Clin Pract. Published 2 May 2025. doi:10.1016/j.diabres.2025.112206

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