Prognostic importance of cardiovascular autonomic neuropathy on cardiovascular and mortality outcomes in individuals with type 2 diabetes: The Rio de Janeiro type 2 diabetes cohort
Authors' conclusion
Low HRV was a better predictor of outcomes than tests of CAN, and it improved risk discrimination.
Study context
- Population
- Individuals with T2D, Rio de Janeiro type 2 diabetes cohortHeart rate variability (HRV) subsample 313
- Participants
- 541 individuals
- Exposure
- Cardiovascular autonomic neuropathy (CAN) / low 24-hour HRV vs absence
- Outcome
- CVEs and all-cause mortality
- Follow-up
- Median 12 years
Methodological detailsmultivariate Cox regression, C-statistics and Integrated Discrimination Improvement (IDI) index
- Multivariate Cox regression
- C-statistics and Integrated Discrimination Improvement (IDI) index
Main finding
As reported in the abstract
CVEs/all-cause mortality · median follow-up 12 years
- CAN associated with excess risks of cardiovascular events (CVEs)/all-cause mortality
- 40%
- Low HRV associated with higher risks of outcomes
- 2-fold
- CVEs, whole cohort
- 177
- All-cause deaths, whole cohort
- 236
- CVEs, subsample
- 96
- All-cause deaths, subsample
- 129
Observational data: associations, not effects.
Further findings
Prevalence of CAN and low HRV
- CAN
- 25%
- Low HRV by SDANN-SDNN
- 17-18%
Risk discrimination for CVEs/mortality with HRV
- Increase in C-statistics up to
- 0.039
- IDIs up to
- 25%
Original publication
Prognostic importance of cardiovascular autonomic neuropathy on cardiovascular and mortality outcomes in individuals with type 2 diabetes: The Rio de Janeiro type 2 diabetes cohort. Diabetes Res Clin Pract. Published 21 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →