Emotional distress, self-management, and glycemic control among participants enrolled in the glycemia reduction approaches in diabetes: A comparative effectiveness (GRADE) study
Authors' conclusion
Depression symptoms and diabetes distress were robustly associated with problematic diabetes self-management among participants in GRADE. These findings highlight the need for routine assessment of depression symptoms and diabetes distress early in T2DM care.
Study context
- Population
- Adults with early T2D enrolled in GRADE; 56 % Non-Hispanic White, 68 % male, mean age 57.96 years, diabetes duration 4.21 years, HbA1c 7.51GRADE substudy
- Participants
- 1,739 adults
- Outcome
- Associations of baseline depression symptoms and diabetes distress with metformin adherence, self-management and HbA1c
- Follow-up
- Baseline
Methodological detailssubstudy of the GRADE study, linear regression adjusted for covariates
- Substudy of the GRADE study
- Linear regression adjusted for covariates
Main finding
As reported in the abstract
Emotional distress vs adherence, self-management and HbA1c
- Prevalence of clinically significant depression
- 8.7 %
- Prevalence of diabetes distress
- 25 %
- Depression symptoms associated with lower self-management (fully adjusted); only significant for somatic symptoms
- p < 0.0001
- Diabetes distress associated with lower adherence
- p = 0.0001
- Diabetes distress associated with lower self-management; significant for all subscales except physician-related distress
- p < 0.0001
Observational data: associations, not effects.
Original publication
Emotional distress, self-management, and glycemic control among participants enrolled in the glycemia reduction approaches in diabetes: A comparative effectiveness (GRADE) study. Diabetes Res Clin Pract. Published 20 December 2022. doi:10.
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