Objective sleep characteristics and continuous glucose monitoring profiles of type 2 diabetes patients in real‐life settings
Authors' conclusion
Objectively determined sleep duration and sleep midpoint, as well as their daily variability, are associated with CGM-derived glucose profiles in T2D patients.
Study context
- Population
- Patients with T2D (aged 62.3 ± 4.8 years, 57% women)
- Participants
- 28 patients
- Outcome
- Association between objective sleep parameters (actigraphy) and CGM-derived glycaemic outcomes (glucose level, TIR, TAR)
Methodological detailsreal-life setting, actigraphy, continous glucose monitoring (CGM), 249 person-days of CGM, 221 nights of sleep characteristics
- Real-life setting
- Actigraphy
- CGM
- 249 person-days of CGM, 221 nights of sleep characteristics
Main finding
As reported in the abstract
Association of SD of objective sleep duration (minutes) between nights with overall CGM outcomes (linear regression)
Glucose level: coefficient (95% CI 0.004, 0.033), P = 0.017
0.018 mmol/L
Time in range (TIR) (% in observation period): coefficient (95% CI −0.36, −0.03), P = 0.023
−0.20%
Time above range (TAR): coefficient (95% CI 0.06, 0.39), P = 0.011
0.22%
Observational data: associations, not effects.
Further findings
Nightly sleep characteristics vs time-matched CGM outcomes (linear mixed models)
- Later sleep midpoint (minutes from midnight) vs SD of glucose during same sleep period: coefficient (95% CI 0.0001, 0.003), P = 0.037
- 0.002 minutes
- Longer nocturnal sleep duration vs CV of glucose in upcoming day (95% CI −0.03, −0.001), P = 0.041
- −0.015%
Original publication
Objective sleep characteristics and continuous glucose monitoring profiles of type 2 diabetes patients in real‐life settings. Diabetes Obes Metab. Published 20 December 2022. doi:10.
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