The impact of sleep status on lipid profiles and incident type 2 diabetes mellitus: a mediation analysis in a Chinese population cohort
Authors' conclusion
Sleep disorders are linked to a higher T2DM risk, with lipid profiles mediating the relationship. Managing lipid metabolism and assessing T2DM risk in those with sleep disorders is key for prevention.
Study context
- Population
- Adults aged 20–74 in Shanghai (2016–2019), followed for new T2DM until 202449,734 eligible
- Participants
- 69,116 adults
- Exposure
- Poor vs good sleep status
- Outcome
- Incident T2DM
- Follow-up
- Until 2024
Methodological detailsmediation analysis
- Mediation analysis
Main finding
As reported in the abstract
New T2DM cases
4,126
Poor overall sleep quality, HR
1.087 (1.016, 1.162) (95% CI)
Poor subjective sleep quality, HR
1.097 (1.007, 1.194) (95% CI)
Sleep disturbances, HR
1.118 (1.038, 1.204) (95% CI)
Observational data: associations, not effects.
Further findings
Mediation by lipid profiles
- Dyslipidemia, total cholesterol (TC) and Chinese Visceral Adiposity Index (CVAI) played a major mediating role in the association between sleep disorders and T2DM
Original publication
The impact of sleep status on lipid profiles and incident type 2 diabetes mellitus: a mediation analysis in a Chinese population cohort. Diabetes Res Clin Pract. Published 9 September 2025. doi:10.
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