Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study
Authors' conclusion
The present etiological study found that worse autonomic function, estimated from lower HRV, was associated with worse beta cell function, estimated from a composite score in a population-based sample which covered the entire spectrum of glucose metabolism. Hence, autonomic dysfunction may contribute to beta cell dysfunction and, ultimately, to the alteration of glucose metabolism status from normal glucose metabolism to prediabetes and type 2 diabetes.
Study context
- Population
- Population-based sample from The Maastricht Study covering the entire spectrum of glucose metabolism; mean age 60 ± 8 years, 52% men, 24% with T2D
- Participants
- 2,007 participants
- Exposure
- Lower vs higher 24-hour heart rate variability (HRV)
- Outcome
- Overall beta cell response composite score (C-peptidogenic index, overall insulin secretion, beta cell glucose sensitivity, potentiation factor and rate sensitivity) during oral glucose tolerance test (OGTT)
Methodological detailspopulation-based, linear regression adjusted for demographic, cardiovascular and lifestyle factors
- Population-based
- Linear regression adjusted for demographic, cardiovascular and lifestyle factors
Main finding
As reported in the abstract
Time-domain HRV, standardized beta [CI]
−0.055
−0.098; −0.011
Frequency-domain HRV, standardized beta [CI]
- 0.051
−0.095; −0.007
Observational data: associations, not effects.
Further findings
- Associations not modified by sex; no consistent pattern of interaction by glucose metabolism status
Original publication
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