Prevention of Hip Fractures: Trade-off between Minor Benefits to Individuals and Large Benefits to the Community
Authors' conclusion
These findings suggest that a population-wide strategy aimed at enhancing BMD across the entire population could lead to a substantial decrease in the incidence of hip fractures.
Study context
- Population
- Participants aged 60+, Dubbo Osteoporosis Epidemiology Study (DOES)
- Exposure
- Second cohort vs initial cohort
- Outcome
- Radiologically ascertained incident hip fracture
Methodological detailstwo cohorts separated by ≈10 years, multivariable-adjusted Cox proportional hazards models, Sensitivity analyses indicated the "effect" was unlikely due to unmeasured confounders
- Two cohorts separated by ≈10 years
- Multivariable-adjusted Cox proportional hazards models
- Sensitivity analyses indicated the "effect" was unlikely due to unmeasured confounders
Main finding
As reported in the abstract
Hip fracture incidence
Second vs InitialHazard ratio (95% CI)
Women
0.54(0.38–0.78)
Men
0.39(0.19–0.80)
Observational data: associations, not effects.
Further findings
| Outcome | Prevalence ratio (95% CI) | |
|---|---|---|
| Prevalence of osteoporosisSecondvs InitialWomen | 0.51 (0.36–0.73) | |
| Prevalence of osteoporosisSecondvs InitialMen | 0.45 (0.24–0.84) | |
| 0.20.5125Prevalence ratio (log scale) |
| Outcome | Difference (g/cm²) |
|---|---|
| Femoral neck BMDSecond vs Initial · women; higher with Second cohort | ≈0.04 |
| Femoral neck BMDSecond vs Initial · men; higher with Second cohort | 0.03 |
Original publication
Prevention of Hip Fractures: Trade-off between Minor Benefits to Individuals and Large Benefits to the Community. J Bone Miner Res. Published 26 September 2023. doi:10.
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