Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development
Authors' conclusion
Together these data suggest a functional association between gram-negative bacterial infections and NHO development
Study context
- Population
- Mice with spinal cord injury (SCI) between vertebrae T11 to T13; human fibro-adipogenic progenitors from muscles surrounding neurogenic heterotopic ossifications (NHO) biopsies; patients with traumatic brain injuries
- Comparison
- Lipopolysaccharides (LPS) exposure vs none in mouse model of NHO induced by SCI
- Outcome
- NHO development
Methodological detailsmouse model of SCI-induced NHO, human cell culture, case-control retrospective study
- Mouse model of SCI-induced NHO
- Human cell culture
- Case-control retrospective study
Main finding
As reported in the abstract
- LPS from gram-negative bacteria exacerbate NHO development in a TLR4-dependent manner, signaling through TRIF/TICAM1 rather than MYD88
- T11 to T13 SCI did not significantly alter intestinal integrity nor cause intestinal bacteria translocation or endotoxemia
- LPS increased expression of osteoblast markers in cultures of human fibro-adipogenic progenitors
- In patients with traumatic brain injuries, infections with gram-negative Pseudomonas species were significantly associated with NHO development
Original publication
Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development. J Bone Miner Res. Published 23 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →