Increased Risk of Vertebral Fractures in Patients With Mild Autonomous Cortisol Secretion
An erratum to this article was published (J Clin Endocrinol Metab, 12 Jul 2024 ↗)
Authors' conclusion
Women and men with AI and MACS are at higher risk of VFx.
Study context
- Population
- Patients with adrenal incidentalomas (AI), 4 Italian endocrinology unitscross-sectional arm
- Participants
- 444 patients
- Exposure
- Mild autonomous cortisol secretion (MACS) vs no MACS
- MACS-yesn = 214
- MACS-non = 230reference
- Outcome
- VFx prevalence (by x-ray); main outcome measures also F-1mgDST and bone mineral density (BMD) by DXA at LS and FN
Methodological detailsretrospective data, multicentre (4 Italian endocrinology units)
- Retrospective data
- Multicentre (4 Italian endocrinology units)
Main finding
As reported in the abstract
Prevalent VFx
MACS-yes vs MACS-noOdds ratio (95% CI)P value
Regardless of age, BMI, gender, LS-BMD and T2D
5.203(3.361–8.055)
P < 0.001- Prevalent VFx
- RR 2.07
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Incident VFx (longitudinal arm: 60 MACS-yes, 66 MACS-no) · 24.9 ± 5.3 months follow-upRegardless of age, LS-BMD, gender, prevalent VFx and T2D | 4.561 (1.600–13.003) | P = 0.005 | |
| 0.050.21520Relative risk (log scale) |
Incident VFx (longitudinal arm: 60 MACS-yes, 66 MACS-no) · 24.9 ± 5.3 months follow-up
- Incident VFx differed between groups (P < .001)
Women and men separately
- Results were confirmed in women and men when separately evaluated
Original publication
Increased Risk of Vertebral Fractures in Patients With Mild Autonomous Cortisol Secretion. J Clin Endocrinol Metab. Published 21 September 2023. doi:10.
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