Inflammatory Markers Link Steroid Profiles to Bone Status in Patients with Autonomous Cortisol Secretion
Authors' conclusion
Inflammatory markers were associated with deteriorated bone quality, especially in premenopausal women with ACS. Androgen deficiency was associated with inflammation, partially contributing to bone deterioration.
Study context
- Population
- Patients with autonomous cortisol secretion (ACS) or nonfunctioning adrenal tumors; analyses stratified by sex and menopausal statussteroid profiles in 64 ACS, 77 nonfunctioning adrenal tumors (NFAT)
- Participants
- 106 vs 95
- Exposure
- ACS vs NFAT
- ACSn = 106
- NFATn = 95reference
- Outcome
- Inflammatory markers (SII, PNI)
Main finding
As reported in the abstract
- Premenopausal women with ACS: SII vs trabecular bone score (TBS) correlation
- r = −0.38
- Premenopausal women with ACS: Prognostic nutritional index (PNI) vs TBS correlation
- r = 0.58
- Androsterone-glucuronide (AND-G) vs SII correlation
- r = −0.59
- AND-G vs PNI correlation
- r = 0.74
- Proportion of AND-G–TBS association mediated by PNI
- 59.9%
Observational data: associations, not effects.
Original publication
Inflammatory Markers Link Steroid Profiles to Bone Status in Patients with Autonomous Cortisol Secretion. J Clin Endocrinol Metab. Published 18 November 2025. doi:10.
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