Benign Adrenal Adenomas Are Associated With Reduced Prevalence of Hospitalised Patients With COVID‐19
Main finding · COVID-19 positivityResult — go to the resultAdjusted odds ratio 0.30 95% CI 0.12–0.74Authors' conclusion
Prevalence of adrenal adenoma was associated with significantly reduced odds of being SARS-CoV2 positive in an inpatient cohort. Secretion of mild excess cortisol (MACS) may be protective against developing severe COVID-19.
Study context
- Population
- Patients undergoing computed tomography pulmonary angiogram (CTPA) at Sheffield Teaching Hospitals, 11 March 2020–10 November 2021; median age 65 (IQR 49–77), 55.0% female
- Participants
- 4,307 CTPA scans
- Exposure
- Benign adrenal adenoma vs no benign adenoma
- Benign adenoman = 76
- Outcome
- COVID-19 positivity (positive test within 2 weeks before CTPA)
Methodological detailssingle-centre
- Single-centre
Main finding
COVID-19 positivity
Adjusted odds ratio
0.30
95% CI 0.12–0.74
P = 0.01
Benign adenomavs No benign adenoma
aOR 0.30 (95% CI 0.12–0.74); P = 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
Prevalence of benign adenoma and COVID-19 positivity
- Benign adenoma
- 76 (1.76%)
- COVID-19 positive
- 897 (20.8%)
Original publication
Benign Adrenal Adenomas Are Associated With Reduced Prevalence of Hospitalised Patients With COVID‐19. Clin Endocrinol (Oxf). Published 6 November 2025. doi:10.
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