Computed Tomography-Based Radiomics Analysis Adds Value to Glycometabolism Assessment in Adrenal Adenoma: An Exploratory Observational Study
Authors' conclusion
A seven-feature CT radiomics signature was independently associated with IGM in patients with adrenal adenoma.
Study context
- Population
- Patients with adrenal adenoma who completed CGM106 analysed
- Participants
- 114 patients
- Exposure
- Impaired glucose metabolism (IGM) vs normal glucose metabolism (NGM)
- IGMn = 58
- NGMn = 48reference
- Outcome
- Association between CT radiomics Rad-score (7 features) and IGM, adjusted for age, BMI and midnight cortisol
Methodological detailsComputed tomography (CT) radiomics, internal validation with 1,000 bootstrap resamples
- CT radiomics
- Internal validation with 1,000 bootstrap resamples
Main finding
As reported in the abstract
Rad-score
IGM
0.377
± 0.510
NGM
−0.029
± 0.808
Rad-scoreEstimate (95% CI)P value
Association with IGM
OR (univariable) 2.718(1.360–5.433)
P = 0.005Association with IGM after multivariable adjustment
adjusted OR 2.681(1.304–5.512)
P = 0.007Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Discrimination of IGM (AUC)Combined model vs Clinical model · DeLong test; not significant | P = 0.101 |
- Discrimination of IGM (AUC) — Clinical model AUC
- 0.623
- Discrimination of IGM (AUC) — Radiomics model AUC
- 0.673
- Discrimination of IGM (AUC) — Combined model AUC
- 0.704
- Discrimination of IGM (AUC) — Combined model bootstrap-corrected AUC
- 0.606
Original publication
Computed Tomography-Based Radiomics Analysis Adds Value to Glycometabolism Assessment in Adrenal Adenoma: An Exploratory Observational Study. Endocr Pract. Published 21 September 2026. doi:10.
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