Metastatic Disease in Phaeochromocytomas and Paragangliomas in Various Genotypes—A Systematic Review and Meta-analysis
Authors' conclusion
We present associations between genotype and metastatic disease in PPGL patients. Our results indicate that patients harboring a pathogenic genetic variant have a higher rate of metastases compared to patients with no identified variant. High heterogeneity in several analyses suggests that further large cohort studies are needed.
Study context
- Population
- Patients with PPGL; studies from PubMed and Embase
- Comparison
- Pathogenic germline/somatic variants vs no identified variant
- Outcome
- Rate of metastatic disease per 100 followed patient-years
Methodological detailsSystematic search of PubMed and Embase
- Systematic search of PubMed and Embase
Pooled result
As reported in the abstract
Metastatic disease rate per 100 patient-years
Further pooled results
Cluster-divided meta-analyses: metastatic disease rate
- Cluster 1
- 4.41
- Cluster 2
- 3.0
Meta-regression: SDHB vs other cluster 1 variants
- Higher rate for SDHB vs other cluster 1 variants
- 2.3-fold
Original publication
Metastatic Disease in Phaeochromocytomas and Paragangliomas in Various Genotypes—A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. Published 3 November 2025. doi:10.
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