Persistent Renin Suppression After Unilateral Adrenalectomy for Primary Aldosteronism: Implications for Adverse Outcome?
Authors' conclusion
Persistent renin suppression is common 6 months after adrenalectomy and associated with worse biochemical but not clinical outcomes. More than 60% of patients with DRC <8 mU/L achieved full biochemical remission.
Study context
- Population
- Patients who underwent unilateral adrenalectomy for lateralized PA, with postoperative renin levels available
- Participants
- 77 patients
- Exposure
- Postoperative direct renin concentrations (DRC) tertiles
- DRC <8 mU/Ln = 26
- DRC 8-16 mU/Ln = 25
- DRC >16 mU/Ln = 26
- Outcome
- Non-classical histopathology (CYP11B2 staining, HISTALDO)
Main finding
As reported in the abstract
P = 0.024
Observational data: associations, not effects.
Further findings
Absent or partial biochemical remission (PASO) · first follow-up — between DRC <8 mU/L and DRC 8-16 mU/L · across the 3 tertiles
P = 0.036
- Absent or partial biochemical remission (PASO) — Complete biochemical remission with DRC <8 mU/L
- 65.4%
Clinical outcomes, incl. end-organ damage and comorbidities · up to 3 years postoperatively
- Did not differ across the tertiles
Original publication
Persistent Renin Suppression After Unilateral Adrenalectomy for Primary Aldosteronism: Implications for Adverse Outcome? J Clin Endocrinol Metab. Published 1 November 2025. doi:10.
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