Electrocardiogram Changes Following Intravenous Bisphosphonate Infusion: A Systematic Review and Meta-Analysis
Pooled result · QTcResult — go to the resultSMD 0.46 ms 95% CI 0.80–0.11Authors' conclusion
Overall, there is a weak association between intravenous bisphosphonate infusion and a QTc interval prolongation.
Study context
- Population
- Patients receiving IV bisphosphonates for any indication; mostly postmenopausal women with osteoporosis (4 studies), also bone metastases (1) and children with osteoporosis secondary to cerebral palsy (1); MEDLINE and EMBASE to January 14, 202311 studies
- Comparison
- Electrocardiogram (ECG) parameters after vs before IV bisphosphonate infusion
- Outcome
- QTc
- Follow-up
- Post-infusion
Methodological detailsrandom-effects models, Newcastle-Ottawa scale quality assessment, 1083 unique records screened; 11 met criteria, Low to low/moderate risk of bias, Study populations ranged from n = 15 to n = 116
- Random-effects models
- Newcastle-Ottawa scale quality assessment
- 1083 unique records screened; 11 met criteria
- Low to low/moderate risk of bias
- Study populations ranged from n = 15 to n = 116
Pooled result
As reported in the abstract
SMD
0.46 ms
95% CI 0.80–0.11
Further pooled results
| Outcome | P value |
|---|---|
| Correlation between pre- and post-infusion QTcPost-infusion vs Pre-infusion · not significant | P = 0.93 |
Heart rate, P wave (max, min), P wave dispersion, PR interval, QRS duration, QTc, QTc (max, min), QTc dispersion
- No differences in these ECG parameters
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Electrocardiogram Changes Following Intravenous Bisphosphonate Infusion: A Systematic Review and Meta-Analysis. J Bone Miner Res. Published 25 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →