Prevalence of Primary Aldosteronism Among Patients With Hypertension
Authors' conclusion
Our study shows a high prevalence of PA in subjects treated as a case of EHTN.
Study context
- Population
- Participants being treated as essential hypertension (EHTN); mean age 49.98 ± 7.76 years, median duration of hypertension 5 (0–24) years59 underwent saline infusion test (SIT)
- Participants
- 492 participants
- Outcome
- Prevalence of PA (positive aldosterone-to-renin ratio (ARR) screening confirmed by recumbent saline infusion test; post-SIT plasma aldosterone concentration (PAC) >5 ng/dL)
Methodological detailsprospective
- Prospective
Main finding
As reported in the abstract
PA confirmed
Positive screening test
91
18.49%
PA confirmed (excluding 32 screened-positive participants non-compliant to SIT)
37 participants
8.04%
Observational data: associations, not effects.
Further findings
Prevalence of PA by grade of hypertension
- Grade 1
- 5.97%
- Grade 3
- 12.03%
- Prevalence increased with grade of hypertension
Prevalence of PA by hypertension daily dose (HDD)
- HDD < 1
- 3.57%
- HDD ≥ 4
- 27.27%
- Prevalence increased with HDD
Hypokalaemia
- PA
- 2.70%
- EHTN
- 3.54%
- No significant difference, p: 0.7815
Original publication
Prevalence of Primary Aldosteronism Among Patients With Hypertension. Clin Endocrinol (Oxf). Published 29 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →