Bioimpedance spectroscopy uncovers extracellular fluid excess in primary aldosteronism
Authors' conclusion
ECW overload in primary aldosteronism can be assessed using bioimpedance spectroscopy. Further research should determine whether addition of this method to current approaches can improve diagnostic accuracy for primary aldosteronism.
Study context
- Population
- Patients with confirmed PA, essential hypertension (EH) and normotensive controls; fluid status measured by bioimpedance spectroscopy
- Participants
- 77 / 90 / 79
- Exposure
- PA vs essential hypertension vs normotensive controls
- PAn = 77
- EHn = 90reference
- Normotensive controlsn = 79reference
- Outcome
- ECW volume (adjusted)
Methodological detailsprospective recruitment
- Prospective recruitment
Main finding
As reported in the abstract
Difference
0.69 ± 1.04 L/m²
P < 0.001 for all
PA vs EH
Difference
0.88 ± 1.04 L/m²
P < 0.001 for all
PA vs Normotensive controls
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Total body waterBetween PA and EH | P = 0.083 |
- Total body water: no significant difference among groups (PA, EH, normotensive controls)
Total body water
- Total body water did not differ significantly among groups
Plasma N-terminal pro-atrial natriuretic peptide
- Plasma N-terminal pro-atrial natriuretic peptide concentration highest in PA
Correlation of PA severity with fluid measures
- PA severity vs extracellular water (ECW) volume (rS)
- 0.31
- PA severity vs overhydration (rS)
- 0.43
- PA severity vs extracellular-to-intracellular water ratio (rS)
- 0.36
- P < .01 for all
Original publication
Bioimpedance spectroscopy uncovers extracellular fluid excess in primary aldosteronism. Eur J Endocrinol. Published 27 April 2026. doi:10.
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