Characteristics of Primary Aldosteronism in a Hypertensive Cohort From Central China
Authors' conclusion
An upright ARR cutoff of 3.71 optimizes PA screening in Central China hypertensives. CT reliability is limited for left-adrenal lateralization, necessitating AVS. Younger hypokalemic patients warrant prioritized unilateral assessment.
Study context
- Population
- Hypertensive patients in Central China
- Participants
- 75 vs 85
- Comparison
- Primary aldosteronism (PA) vs essential hypertension
- PAn = 75
- Essential hypertensionn = 85reference
- Outcome
- Region-specific diagnostic thresholds and subtype characterization for PA
Main finding
As reported in the abstract
Upright ARR for PA screening
Optimal upright ARR cutoff
> 3.71 [ng/dL]/[ng/L]
AUC
0.919
Observational data: associations, not effects.
Further findings
Captopril challenge test vs saline infusion test (PA)
- Identical positivity
- 61.9%
- Concordance (κ)
- −0.01
Computed tomography (CT) vs adrenal venous sampling (AVS) lateralization (PA)
- CT left-sided lesions bilateral on AVS
- 55.6%
- CT "bilateral" findings unilateral on AVS
- 37.5%
- Right-sided/CT-normal cases AVS concordance
- 100%
- n = 2 requires validation
Unilateral vs bilateral PA characteristics
- Unilateral PA younger (P = .027)
- Unilateral PA lower potassium (P = .059)
Original publication
Characteristics of Primary Aldosteronism in a Hypertensive Cohort From Central China. Endocr Pract. Published 30 July 2025. doi:10.
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