Weight gain reversibility and body mass index (BMI) following treatment for Cushing’s syndrome: long-term outcomes and potential predictors
Authors' conclusion
Approximately half of CS patients in remission achieved at least 5% decrease in BMI with long-term follow-up, and a third achieved more than 10% decrease. Disease remission, female gender, baseline BMI ≥ 30, and early BMI reduction, predicted a clinically significant weight loss.
Study context
- Population
- Patients with Cushing's syndrome (CS) (67.2% female, mean age 51.6 ± 17.4 years) and matched controls; patients taking GLP-1 excludedmatched cohort
- Participants
- 308 vs 1,020
- Exposure
- CS patients vs matched controls; weight and BMI change after treatment
- CSn = 308
- Controlsn = 1,020reference
- Outcome
- Reversibility of weight gain (absolute weight and BMI decrease) following treatment for CS
- Follow-up
- One year post-diagnosis and end
Methodological detailsage-, sex- and BMI-matched controls (up to five per case), Clalit Health Services database
- Age-, sex- and BMI-matched controls (up to five per case)
- Clalit Health Services database
Main finding
As reported in the abstract
Weight reduction in CS patients in remission (kg)
85.1 ± 21.0 to 80.8 ± 22.7
BMI decrease in CS patients in remission (kg/m², p < 0.01)
31.6 ± 7.4 to 29.9 ± 7.4
Observational data: associations, not effects.
Further findings
Weight and BMI in CS patients at end of follow-up · 8.6 years
- Weight in CS (kg, p < 0.01)
- 85.0 ± 22.3 to 81.3 ± 22.8
- BMI in CS (kg/m², p < 0.01)
- 31.2 ± 7.6 to 29.9 ± 7.6
- Controls showed slight increases in both weight and BMI
Weight loss among patients in remission at end of follow-up
- ≥ 5% weight loss
- 44.0% (77/175)
- ≥ 10% weight loss
- 30.3% (53/175)
Weight change in persistent CS
- Patients with persistent CS exhibited no significant weight changes
Predictors of ≥ 5% weight loss (multivariate analysis)
- Female gender, baseline BMI ≥ 30 and BMI decrease ≥ 1 kg/m² at one year predicted ≥ 5% weight loss
Original publication
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