Prevalence of impaired awareness of hypoglycaemia in people with diabetes mellitus: A systematic review and meta‐analysis from 21 countries and regions
Authors' conclusion
IAH is a prevalent risk event among people with type 1 and type 2 diabetes, showing clinical heterogeneity and regional variability. UAH, an adverse progression of IAH, is also a serious burden. More primary research on the prevalence of IAH is needed in areas with a high diabetes burden.
Study context
- Population
- People with diabetes in cross-sectional and cohort studies reporting impaired awareness of hypoglycaemia (IAH) prevalence; 21 countries, published 2000–2022
- Participants
- 39,180 people62 studies
- Outcome
- Pooled prevalence of impaired awareness of hypoglycaemia (IAH) and unawareness of hypoglycaemia (UAH)
Methodological detailsrandom-effects model, subgroup analysis, meta-regression, Databases searched from inception to 8 August 2022
- Random-effects model
- Subgroup analysis
- Meta-regression
- Databases searched from inception to 8 August 2022
Pooled result
As reported in the abstract
Pooled prevalence of IAH
Clarke questionnaire
23.2%
95% CI 18.4%–29.3%
Gold score
26.2%
95% CI 22.9%–29.9%
Pedersen-Bjergaard method
58.5%
95% CI 53.0%–64.6%
Further pooled results
Prevalence of unawareness of hypoglycaemia (UAH) (Pedersen-Bjergaard method)
- Prevalence of UAH
- 17.6 (95% CI: 14.9%-20.3%)
IAH prevalence by diabetes type and region
- IAH prevalence generally higher in T1D than T2D and lowest in Europe
Meta-regression
- Duration of diabetes was a factor influencing IAH prevalence
Original publication
Prevalence of impaired awareness of hypoglycaemia in people with diabetes mellitus: A systematic review and meta‐analysis from 21 countries and regions. Diabet Med. Published 18 May 2023. doi:10.
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