Prevalence and predictive features of metabolic dysfunction-associated steatotic liver disease in type 1 diabetes
Authors' conclusion
Individuals with type 1 diabetes and high blood pressure, older age, higher BMI, and longer duration of disease could be considered at high-risk for developing MASLD.
Study context
- Population
- Individuals with T1D (41.6 ± 15.0 years, 64% female, BMI 25.4 ± 4.2 kg/m², HbA1c 55.6 ± 12 mmol/mol)
- Participants
- 453 individuals
- Outcome
- Prevalence and severity of MASLD: steatosis (CAP ≥280.0 dB/m) and fibrosis (LMS ≥8.0 kPa) on vibration-controlled transient elastography (VCTE)
Methodological detailsvibration-controlled transient elastography, machine learning Extra-Trees classification model
- Vibration-controlled transient elastography
- Machine learning Extra-Trees classification model
Main finding
As reported in the abstract
Hepatic steatosis prevalence
9.5%
95% CI 6.8–12.2
Fibrosis prevalence
3.5%
95% CI 1.8–5.2
Observational data: associations, not effects.
Further findings
Features associated with higher LMS
- Higher LMS was associated with longer T1D duration, older age, higher BMI and higher controlled attenuation parameter (CAP) score
Prediction of fibrosis (Extra-Trees model)
- AUC, mean ± SD
- 0.73 ± 0.03
- Most important predictive features: T1D duration, age, systolic blood pressure
Original publication
Prevalence and predictive features of metabolic dysfunction-associated steatotic liver disease in type 1 diabetes. Eur J Endocrinol. Published 29 April 2024. doi:10.
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