Preserved cardiac vagal tone is associated with nocturnal glycaemic stability
Authors' conclusion
Preserved CVT, indicating normal central parasympathetic tone, is associated with a stable and dynamically regulated glucose profile with reduced adverse glucose mobilisation during sleep.
Study context
- Population
- Individuals without diabetes and with T2D, aged 45–75 years; nocturnal ECG-derived cardiac vagal tone (CVT) (ProCVT SmartSheet) and Dexcom G6 continuous glucose monitoring (CGM)N=50 analysed
- Exposure
- Normal CVT vs poor CVT
- Outcome
- Association between CVT and CGM outcomes during sleep
Methodological details72 h home monitoring, blinded CGM
- 72 h home monitoring
- Blinded CGM
Main finding
As reported in the abstract
Higher nocturnal CVT predicted lower glucose CV
β=−0.8
p=0.030
Higher nocturnal CVT predicted greater time in tight range
β=5.2
p=0.001
Observational data: associations, not effects.
Further findings
Higher CVT and CGM outcomes, individuals without diabetes
- Reduced risk of hyperglycaemia
- −10.2%, p=0.015
- Reduced TAR
- −11.8%, p=0.015
- Reduced time in moderate hyperglycaemia
- −11.8%, p=0.015
- Increased glucose mobility
- β=0.014, p=0.029
Poor CVT at 15 min segment level and glucose in subsequent period, all individuals
- Increase in glucose with poor CVT
- 1.9%, p=0.049
Original publication
Preserved cardiac vagal tone is associated with nocturnal glycaemic stability. Diabetologia. Published 9 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →