Prepregnancy Body Mass Index and Risk of Differentiated Thyroid Cancer: A Prospective Cohort Study of More than 440,000 Danish Women
Authors' conclusion
Our study confirms that excess body weight is associated with an increased incidence of DTC and PTC in women.
Study context
- Population
- Parous Danish women with prepregnancy body mass index (BMI) ≥18.5 kg/m² registered 2004–2016 in the Danish Medical Birth Registry; median age at baseline 30.0 years463 differentiated thyroid cancer (DTC) cases
- Participants
- 443,403 women
- Exposure
- Excess body weight vs normal weight
- Outcome
- DTC
Methodological detailsregistry-based, Cox proportional hazards regression, adjusted for calendar time, education, smoking status, benign thyroid disease, T2D, parity and oral contraceptive use
- Registry-based
- Cox proportional hazards regression
- Adjusted for calendar time, education, smoking status, benign thyroid disease, T2D, parity and oral contraceptive use
Main finding
As reported in the abstract
Each group vs normal weightHazard ratio (CI)
Overweight
1.54(1.25–1.90)
Obese
1.32(1.00–1.75)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| DTC per 5 kg/m² increase in BMI (continuous) | 1.17 (1.07–1.27) | |
| 0.512Hazard ratio (log scale) |
Papillary thyroid cancer (PTC)
- Results were similar in PTC
DTC in women without previous benign thyroid disease
- Results similar in women without previous benign thyroid disease
Original publication
Prepregnancy Body Mass Index and Risk of Differentiated Thyroid Cancer: A Prospective Cohort Study of More than 440,000 Danish Women. Thyroid. Published 15 November 2022. doi:10.
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