The first epidemiological study of presymptomatic type 1 diabetes among first-degree relatives in Japan: PREP-T1D study
Authors' conclusion
From this first study describing the epidemiological characteristics of presymptomatic T1D in Japan and Asia, it was shown that the prevalence of IAbs in Japan was comparable to that in other countries, underscoring the importance of screening and monitoring for presymptomatic T1D in Japan as well.
Study context
- Population
- First-degree relatives of individuals with T1D in Japan, 71 sites
- Participants
- 2,614 relatives
- Outcome
- Prevalence of islet autoantibody (IAb) positivity / presymptomatic T1D
Methodological detailsnationwide, multicentre, observational
- Nationwide
- Multicentre
- Observational
Main finding
As reported in the abstract
IAb positivity
Islet autoantibody (IAb) positivity (≥1 IAb)
95 participants
3.6%
Multiple-IAb positivity
16
0.6%
ZnT8A among IAb-positive
49.5%, 47 of 95
GADA among IAb-positive
42.1%, 40
Observational data: associations, not effects.
Further findings
Presymptomatic stage classification
- Stage 1
- 5 participants
- Stage 2
- 9
- Stage 3
- 2
HLA alleles and haplotypes
- Most common HLA-A allele A*24:02
- 36.8%
- DRB1-DQB1 haplotype *09:01-*03:03
- 24.2%
- DRB1-DQB1 haplotype *04:05-*04:01
- 23.6%
Original publication
The first epidemiological study of presymptomatic type 1 diabetes among first-degree relatives in Japan: PREP-T1D study. Diabetes Res Clin Pract. Published 1 June 2026. doi:10.
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