Premature pubarche in Prader‐Willi syndrome: Risk factors and consequences
Authors' conclusion
PP is common in PWS but does not compromise final height in comparison to the NP group. Obesity and insulin resistance were not associated with PP in children with PWS, contrary to what has been seen in obese children without PWS.
Study context
- Population
- Children with Prader-Willi syndrome treated at one institution, 1990–2021
- Participants
- 43 children
- Exposure
- Prader-Willi Syndrome (PWS) with premature pubarche vs normal pubarche
- Premature pubarche (PP)n = 23
- Normal pubarche (NP)n = 20reference
- Outcome
- Frequency of PP, and its potential precursors and sequelae, in PWS
Methodological detailschart review, single-centre
- Chart review
- Single-centre
Main finding
As reported in the abstract
Frequency of PP
Observational data: associations, not effects.
Further findings
Age at pubarche
HDL · lower HDL with PP
P = 0.041
- Difference between target and final height · did not differ
- P = 0.507
Age at pubarche
- Age at pubarche not correlated with age of recombinant human growth hormone (rhGH) initiation, body mass index (BMI) z-score or homeostasis model assessment of insulin resistance (HOMA-IR) at pubarche
BMI z-score at pubarche vs degree of pubarchal BA advancement
- Modestly correlated
- P = 0.033
Original publication
Premature pubarche in Prader‐Willi syndrome: Risk factors and consequences. Clin Endocrinol (Oxf). Published 27 June 2024. doi:10.
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