Lean Body Mass in Boys With Prader-Willi Syndrome Increases Normally During Spontaneous and Induced Puberty
Authors' conclusion
Boys with PWS showed a recognizable increment in LMI during both spontaneous and induced puberty compared with the prepubertal phase, which was within the trajectories of normal boys. Therefore, timely testosterone substitution in the absence or at arrest of puberty during growth hormone treatment is important to optimize peak LBM in PWS.
Study context
- Population
- Boys with genetically proven PWS on internationally standardized GH treatment, puberty induced upon pubertal arrest, primary referral centre for PWS; mean age at puberty onset 12.3 years; data from 4 years before to 4 years after puberty onset
- Participants
- 13 participants
- Exposure
- Prepubertal vs post-pubertal-onset lean mass index (LMI) increment
- Outcome
- Lean mass index (LMI) by DXA
Methodological detailssingle-centre, Mean observation period 2.9 years before and 3.1 years after puberty onset
- Single-centre
- Mean observation period 2.9 years before and 3.1 years after puberty onset
Main finding
As reported in the abstract
LMI increase
LMI increase per year before puberty
0.28 kg/m²
LMI increase per year after onset of puberty
0.74 kg/m²
Variation in LMI explained by time before puberty
less than 10%
Variation in LMI explained by time after puberty onset
about 25%
Observational data: associations, not effects.
Original publication
Lean Body Mass in Boys With Prader-Willi Syndrome Increases Normally During Spontaneous and Induced Puberty. J Clin Endocrinol Metab. Published 6 March 2023. doi:10.
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