Health-related Quality of Life and Problem Behavior After GH Cessation in Adults Born Small for Gestational Age: A 12-Year Follow-up Study
Authors' conclusion
During 12 years after GH cessation, HRQoL remained mostly similar and problem behavior decreased in SGA-GH adults. SGA-GH and SGA-S adults had similar HRQoL and problem behavior. All SGA adults had lower HRQoL and more internalizing problem behavior than AGA adults.
Study context
- Population
- Adults born small for gestational age (SGA) treated with GH during childhood, followed 12 years after GH cessation, and age-matched controls at age around 30 years
- Participants
- 176 / 50 / 77 / 99
- Exposure
- SGA adults after childhood GH cessation (SGA-GH) vs untreated SGA-S, SGA-CU and AGA controls
- SGA-GHn = 176
- SGA-Sn = 50
- SGA-CUn = 77
- AGAn = 99reference
- Outcome
- HRQoL (TNO-AZL Adults Quality of Life questionnaire) and problem behavior (Adolescent Behavior Check List)
- Follow-up
- 6 months and 2, 5 and 12 years after GH cessation
Methodological details12-year follow-up, 3 untreated age-matched control groups
- 12-year follow-up
- 3 untreated age-matched control groups
Main finding
As reported in the abstract
12 years after GH cessation
- In SGA-GH, health-related quality of life (HRQoL) remained similar on 9 subscales but decreased on 3 subscales (gross motor functioning, pain, sleep) during 12 years after GH cessation
- Externalizing problem behavior decreased significantly; internalizing problem behavior tended to decrease
- SGA-GH and SGA-S had similar HRQoL and problem behavior
- SGA-GH vs AGA: similar HRQoL on 7 subscales, lower on 5 subscales, more internalizing and externalizing problem behavior
- All SGA adults had lower HRQoL and more internalizing problem behavior than AGA adults
Observational data: associations, not effects.
Further findings
- Adult height associated negatively with externalizing problem behavior, but the influence was small
Original publication
Health-related Quality of Life and Problem Behavior After GH Cessation in Adults Born Small for Gestational Age: A 12-Year Follow-up Study. J Clin Endocrinol Metab. Published 18 June 2024. doi:10.
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