Cerebrovascular Abnormalities in Adults Born Small for Gestational Age (SGA) at 12 Years After Growth Hormone Cessation Compared to Controls
Authors' conclusion
Our findings suggest that SGA-GH adults at 12 years after GH cessation have no increased prevalence of cerebrovascular abnormalities compared to appropriate controls. Further research is needed to confirm our findings.
Study context
- Population
- Adults born SGA at 12 years after cessation of childhood growth hormone (GH) treatment and untreated controls; brain magnetic resonance imaging (MRI) May 2016–December 2020
- Participants
- 301 adults
- Exposure
- Adults born SGA treated with GH in childhood vs 3 untreated control groups
- Outcome
- Cerebrovascular abnormalities
- Follow-up
- 12 years after cessation of childhood GH treatment
Methodological detailssingle-centre, blinded MRI scoring by 2 neuroradiologists, 3T MRI
- Single-centre
- Blinded MRI scoring by 2 neuroradiologists
- 3T MRI
Main finding
As reported in the abstract
Cerebrovascular abnormalities on MRI
Aneurysms: SGA-GH 3 (3.6%), SGA-S 1 (2.9%), AGA 2 (2.2%); no differences between SGA-GH and controls
6 adults
Previous intracerebral hemorrhages only in SGA-S
2
4.8%
Microbleeds: SGA-GH 4 (4.3%), SGA-S 4 (9.5%), SGA-CU 3 (4.3%), AGA 6 (6.3%); no differences between SGA-GH and controls
17 adults
Observational data: associations, not effects.
Original publication
Cerebrovascular Abnormalities in Adults Born SGA at 12 Years After Growth Hormone Cessation Compared to Controls. J Clin Endocrinol Metab. Published 19 October 2023. doi:10.
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