Preimplantation genetic testing for type 2 diabetes based on family-specific polygenic risk score: A proof-of-concept study
Authors' conclusion
Our study provided preliminary evidence for the feasibility of developing a more accurate polygenic risk prediction model using pedigree information and its application in embryo selection.
Study context
- Population
- Infertile couple with a family history of early-onset T2D
- Outcome
- Family-specific polygenic T2D risk prediction for embryo selection
Methodological detailssingle family
- Single family
Main finding
As reported in the abstract
Family-specific polygenic T2D risk model: T2D risk SNPs, weighted by genotype-phenotype correlation in the pedigree
114
Newborn had the same lowest T2D polygenic risk and normal growth and development; follow-up (months)
16
Original publication
Preimplantation genetic testing for type 2 diabetes based on family-specific polygenic risk score: A proof-of-concept study. Diabetes Res Clin Pract. Published 13 May 2025. doi:10.
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