Gestational diabetes & diabetes in pregnancy
Pregnancy and postpartum cardiometabolic outcomes among women with overt diabetes compared to women with normoglycaemia, gestational diabetes and pre‐existing diabetes: A systematic review and meta‐analysis
Authors' conclusion
This SRM demonstrates that ODiP is associated with significantly worse pregnancy and postpartum outcomes compared with GDM and normoglycaemia in pregnancy. These findings underscore the need for targeted clinical strategies to manage ODiP and mitigate adverse maternal and neonatal outcomes.
Study context
- Population
- Pregnant women with overt diabetes in pregnancy (ODiP), gestational diabetes mellitus (GDM), pre-existing diabetes or normoglycaemia; studies published January 1, 2010, to May 31, 2024 (PubMed, Embase, Scopus)
- Participants
- 16,135 pregnancies11 studies
- Comparison
- Overt diabetes in pregnancy (ODiP) vs GDM, pre-existing diabetes (PED) and normoglycaemia
- Outcome
- Maternal pregnancy outcomes, ODiP vs GDM
Pooled result
As reported in the abstract
ODiP vs GDMRelative risk (95% CI)
Gestational hypertension
1.93(1.45–2.58)
Pre-eclampsia
1.65(1.26–2.16)
Caesarean delivery
1.14(1.01–1.29)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Adverse neonatal outcomes, ODiP vs GDMODiPvs GDMLarge for gestational age | 1.45 (1.13–1.85) | |
| Adverse neonatal outcomes, ODiP vs GDMODiPvs GDMMacrosomia | 1.66 (1.05–2.64) | |
| Adverse neonatal outcomes, ODiP vs GDMODiPvs GDMNeonatal hypoglycaemia | 1.52 (1.06–2.19) | |
| Adverse neonatal outcomes, ODiP vs GDMODiPvs GDMStillbirth | 4.30 (1.69–10.98) | |
| 0.050.21520Relative risk (log scale) |
Postpartum diabetes
- Risk of postpartum diabetes with ODiP vs GDM
- 6 times higher
- Risk of postpartum diabetes with ODiP vs normoglycaemia
- 25 times higher
- Variations in diagnostic criteria and postpartum follow-up duration contributed to heterogeneity
Original publication
Pregnancy and postpartum cardiometabolic outcomes among women with overt diabetes compared to women with normoglycaemia, gestational diabetes and pre‐existing diabetes: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 11 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →