Gestational diabetes & diabetes in pregnancy
Pregnancy outcomes in women with young‐onset type 2 diabetes: the impact of age of diabetes diagnosis and duration of diabetes
Authors' conclusion
An earlier age of YT2DM diagnosis and/or longer duration of YT2DM were associated with excess GWG and a higher mean-pregnancy HbA1c. Rates of pre-eclampsia and proteinuria were increased in T2D30, likely mediated at least in part by factors such as glycaemia. Our findings suggest that the age of YT2DM diagnosis and/or duration of YT2DM, not just maternal age, should be considered when assessing pregnancy risks.
Study context
- Population
- Pregnant women with pre-gestational young-onset T2D (diagnosed <40 years), 2010–2019
- Participants
- 66 vs 69
- Exposure
- T2D diagnosed at <30 years vs at 30 to <40 years
- T2D30n = 66
- T2D40n = 69reference
- Outcome
- Co-primary: preterm delivery, large for gestational age (LGA) infants, and pre-eclampsia
Methodological detailsretrospective analysis (2010-2019)
- Retrospective analysis (2010-2019)
Main finding
As reported in the abstract
- Similar rates of preterm delivery and large for gestational age (LGA) infants in both groups
- Rates of pre-eclampsia increased in T2D30, although significance was lost following adjustment for factors such as glycaemia
Observational data: associations, not effects.
Further findings
Excess gestational weight gain (GWG)
- T2D30 had at least a twofold increase in the adjusted odds of excess GWG
Proteinuria
- Rates of proteinuria increased in T2D30, significance lost after adjustment
Mean pregnancy HbA1c and excess GWG by age of YT2DM diagnosis and duration (continuous)
- Younger age of YT2DM diagnosis and longer duration, but not maternal age, independently associated with higher mean pregnancy HbA1c and excess GWG
- P < 0.05 for both
Baseline characteristics
- T2D30 significantly younger, longer diabetes duration, higher smoking rates vs T2D40
- P < 0.05 for all
- Obesity in both groups
- ≥60%
Original publication
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