Gestational diabetes & diabetes in pregnancy
One-hour vs Two-hour Postprandial Glucose Targets and Fetomaternal Outcomes in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
Pooled result · LGAResult — go to the resultOdds ratio 0.54 95% CI 0.32–0.93Authors' conclusion
Our findings suggest that targeting 1 hPG <140 mg/dL vs 2 hPG<120 mg/dL lowers the risk of LGA, but does not affect other parameters. A stricter target of 1 hPG<120 mg/dL can increase the risk of preterm delivery. Further studies to corroborate these findings are necessary.
Study context
- Population
- Women with gestational diabetes mellitus (GDM) undergoing 1 hPG vs 2 hPG monitoring6 articles
- Comparison
- 1-hour PPG target vs 2-hour PPG target in GDM
- Outcome
- LGA and macrosomia
Pooled result
LGA
Odds ratio
0.54
95% CI 0.32–0.93
P = 0.03
1 hPG<140 mg/dLvs 2 hPG<120 mg/dL
OR 0.54 (95% CI 0.32–0.93); P = 0.03
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Macrosomia (primary outcome)1 hPG<140 mg/dLvs 2 hPG<120 mg/dL | 0.45 (0.19–1.06) | P = 0.07 | |
| LBW1 hPG<140 mg/dLvs 2 hPG<120 mg/dL | 0.90 (0.30–2.68) | P = 0.85 | |
| Neonatal hypoglycemia1 hPG<140 mg/dLvs 2 hPG<120 mg/dL | 0.60 (0.28–1.26) | P = 0.18 | |
| Cesarean section1 hPG<140 mg/dLvs 2 hPG<120 mg/dL | 0.99 (0.46–2.12) | P = 0.97 | |
| Pre-eclampsia1 hPG<140 mg/dLvs 2 hPG<120 mg/dL | 0.66 (.22-1.96) | P = 0.46 | |
| Need for insulin therapy1 hPG<140 mg/dLvs 2 hPG<120 mg/dL | 1.39 (.79-2.43) | P = 0.25 | |
| Preterm delivery: 1 hPG<120 mg/dLvs 1 hPG<140 mg/dL (3 articles) | 1.62 (1.00–2.62) | P = 0.05 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Mean difference (g) (95% CI) | P value | |
|---|---|---|---|
| Birthweight1 hPG<140 mg/dLvs 2 hPG<120 mg/dL | −61.77 (−152.16-28.62) | P = 0.018 | |
| −200−1000100Difference, g (linear scale) |
| Outcome | Mean difference (weeks) (95% CI) | P value | |
|---|---|---|---|
| Gestational age at delivery1 hPG<140 mg/dLvs 2 hPG<120 mg/dL | 0.20 (−0.29-0.68) | P = 0.43 | |
| −0.500.51Difference, weeks (linear scale) |
Preterm delivery: 1 hPG<120 mg/dL vs 1 hPG<140 mg/dL (3 articles)
- No effect on birthweight, large-for-gestational age (LGA), macrosomia, low birthweight (LBW) and cesarean section (CS) with 1 hPG<120 vs <140 mg/dL
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
One-hour vs Two-hour Postprandial Glucose Targets and Fetomaternal Outcomes in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Endocr Pract. Published 21 May 2025. doi:10.
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