Pregnancy induces longitudinal changes in urinary C‐peptide creatinine ratio in women with type 1 diabetes
Authors' conclusion
UCPCR detects longitudinal changes during pregnancy in women with type 1 diabetes mellitus, more marked in those with shorter diabetes duration.
Study context
- Population
- Pregnant women with T1D, followed through the three trimesters and postpartum
- Participants
- 26 women
- Outcome
- Changes in urinary C-peptide creatinine ratio (UCPCR) during pregnancy and postpartum
- Follow-up
- First, second and third trimester, and postpartum
Methodological detailsUrinary C-peptide creatinine ratio (UCPCR) measured with a high-sensitivity two-step chemiluminescent microparticle immunoassay
- UCPCR measured with a high-sensitivity two-step chemiluminescent microparticle immunoassay
Main finding
As reported in the abstract
Detectable UCPCR
Detectable UCPCR, first trimester
7 of 26
26.9%
Detectable UCPCR, second trimester
10 of 26
38.4%
Detectable UCPCR, third trimester
18 of 26
69.2%
Observational data: associations, not effects.
Further findings
Factors associated with UCPCR concentration
- UCPCR in all three trimesters associated with shorter diabetes duration; in third trimester also with first-trimester UCPCR
Original publication
Pregnancy induces longitudinal changes in urinary C‐peptide creatinine ratio in women with type 1 diabetes. Diabet Med. Published 26 June 2023. doi:10.
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