Preeclampsia as an independent predictor of atherosclerosis progression in women with type 1 diabetes: a 5-year prospective study
Authors' conclusion
PE was a strong independent predictor of atherosclerosis progression over a 5-year follow-up period, with an additive effect in T1D. These findings highlight preeclampsia as a significant CVD risk enhancer in young women with T1D.
Study context
- Population
- Women with or without T1D and with or without a history of preeclampsia (PE); mean age at inclusion 45.2 ± 7.6 years104 completed follow-up
- Participants
- 112 women
- Exposure
- T1D and/or preeclampsia vs neither
- T1D + /PE +n = 28
- T1D + /PE-n = 28
- T1D-/PE +n = 28
- T1D-/PE-n = 28reference
- Outcome
- Atherosclerosis progression: increase in carotid plaque number or a cardiovascular event (fatal or non-fatal ischemic heart disease, fatal or non-fatal stroke, and/or HF)
- Follow-up
- 5 years (mean 5.3 ± 1.2 years)
Main finding
As reported in the abstract
Atherosclerosis progression · 5 years
Odds ratio (CI)P value
PE
4.97(1.61–15.29)
P = 0.005PE + T1D
7.69(1.25–47.29)
P = 0.028Observational data: associations, not effects.
Further findings
Increase in carotid plaques and cardiovascular events (all women) · mean follow-up
- Increase in carotid plaques
- 34 women (32.7%)
- Cardiovascular events
- 3 (2.9%)
Original publication
Preeclampsia as an independent predictor of atherosclerosis progression in women with type 1 diabetes: a 5-year prospective study. Cardiovasc Diabetol. Published 9 April 2025. doi:10.
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