Apelin and Myostatin Levels in Adolescents With Type‐1‐Diabetes
Authors' conclusion
Our results demonstrate lower levels of apelin, a myokine related to the beneficial metabolic effects of skeletal muscle, in prolonged T1D.
Study context
- Population
- Adolescents with recent-onset T1D, prolonged T1D, and healthy controls
- Participants
- 58 adolescents
- Exposure
- Prolonged T1D vs recent-onset T1D vs healthy controls
- Prolonged T1Dn = 20
- Recent-onset T1Dn = 20
- Healthy controlsn = 18reference
- Outcome
- Levels and clinical correlates of a panel of five myokines (apelin, irisin, IL-6, FGF21, myostatin)
Main finding
As reported in the abstract
Apelin levels
Analysis of variance (ANOVA) p = 0.029
Observational data: associations, not effects.
Further findings
Correlation of apelin with fasting C-peptide
- Apelin vs fasting C-peptide, r
- r = 0.337, p = 0.010
Correlation of myostatin with insulin doses (prolonged T1D)
- Myostatin vs total daily dose, r
- r = 0.590, p = 0.006
- Myostatin vs basal daily dose, r
- r = 0.645, p = 0.002
Correlation with diastolic blood pressure (BP) percentile
- Apelin vs diastolic BP percentile, r
- r = - 0.324, p = 0.013
- Myostatin vs diastolic BP percentile, r
- r = - 0.302, p = 0.024
Original publication
Apelin and Myostatin Levels in Adolescents With Type‐1‐Diabetes. Pediatr Diabetes. Published 8 April 2025. doi:10.
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