Predictors of diabetes remission after bariatric surgery in patients with type 2 diabetes mellitus duration ≥ 10 years: A retrospective cohort study
Authors' conclusion
%TWL and β-cell function are significantly associated with diabetes remission after bariatric surgery in long-duration T2DM patients, with restored first-phase insulin secretion still observed.
Study context
- Population
- Patients with T2D duration ≥ 10 years who underwent bariatric surgery; 59.6 % treated with insulin before surgery
- Participants
- 203 patients
- Outcome
- Predictors of diabetes remission (HbA1c < 6.5 % (48 mmol/mol) at least 3 months after discontinuation of hypoglycemic drugs)
- Follow-up
- One year post-surgery
Main finding
As reported in the abstract
Predictors of remission at 1 year post-surgery (Cox regression)
β-cell function, HR
1.20
95 % CI 1.03–1.40
%TWL, HR
1.04
95 % CI 1.01–1.07
Observational data: associations, not effects.
Further findings
Remission rates post-surgery · 1, 2 and 3 years
- 1-year remission rate
- 65.6 %
- 2-year remission rate
- 53.8 %
- 3-year remission rate
- 41.9 %
- Decrease per year
- ∼10 %
First-phase insulin secretion (intravenous glucose tolerance test (IVGTT)) in patients with remission
- First-phase insulin secretion peak vs fasting insulin level, in 50 patients with remission
- ≈5-8 folds
Original publication
Predictors of diabetes remission after bariatric surgery in patients with type 2 diabetes mellitus duration ≥ 10 years: A retrospective cohort study. Diabetes Res Clin Pract. Published 8 April 2025. doi:10.
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