Predictors of biochemical remission after transsphenoidal surgery in a large cohort of acromegaly patients
Authors' conclusion
Lesions which failed to achieve biochemical remission appeared to display distinctive preoperative endocrinological characteristics, with preoperative IGF-1 levels and percentage changes in IGF-1 levels being predictive of biochemical remission status.
Study context
- Population
- Patients with symptomatic acromegaly undergoing transsphenoidal surgery (TSS) at an academic tertiary care center38 excluded
- Participants
- 158 patients
- Exposure
- Failed remission vs remission after TSS
- Outcome
- Factors predictive of biochemical remission, as defined by the 2022 Acromegaly Consensus Conference guidelines
Methodological detailssingle institution, longitudinal, academic tertiary care center
- Single institution
- Longitudinal
- Academic tertiary care center
Main finding
As reported in the abstract
Predictors of remission failure (multivariable logistic regression)
Preoperative IGF-1 magnitude: OR
1.001
95% CI 1.00, 1.003
Percentage change in IGF-1: OR
1.021
95% CI 1.01, 1.04
Observational data: associations, not effects.
Further findings
Preoperative raw IGF-1
GH hypersecretion · preoperative · trended towards higher rates
Postoperative GH and IGF-1
- Failed remission had higher postoperative GH and IGF-1 levels and a lower percentage reduction in raw IGF-1
Tumor and surgery characteristics
- Intrasellar macroadenomas
- 75%
- Endoscopic surgery
- 98.3%
Original publication
Predictors of biochemical remission after transsphenoidal surgery in a large cohort of acromegaly patients. Pituitary. Published 21 December 2024. doi:10.
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