Clinical Characteristics, and Prevalence of Hepatic and Bone Mineral Density Abnormalities in Patients With Sheehan Syndrome: Data From a Tertiary Care Center
Authors' conclusion
Patients with SS had a lower sella turcica volume than controls. Additionally, 90% of patients had osteoporosis or osteopenia, and many also had hepatic steatosis or fibrosis.
Study context
- Population
- Patients with Sheehan syndrome (postpartum pituitary necrosis) and healthy controls, tertiary care center
- Comparison
- Sheehan syndrome vs healthy controls
- Sheehan syndrome (SS)n = 50
- Outcome
- Clinical profile of SS, sella turcica volume, liver fat and BMD
Methodological detailssingle tertiary care centre
- Single tertiary care centre
Main finding
As reported in the abstract
Sella turcica volume
P ≤ 0.01
Observational data: associations, not effects.
Further findings
Age
P = 0.55
BMI
P = 0.86
Clinical features and pituitary hormone deficiencies in SS
- Lactational failure
- 88%
- Secondary amenorrhea
- 96%
- GH deficiency
- 94%
- Hypogonadism
- 96%
- Thyrotroph failure
- 96%
- Corticotroph failure
- 92%
Hepatic steatosis and fibrosis in SS
- Mild steatosis
- 4%
- Moderate steatosis
- 8%
- Severe steatosis
- 12%
- Mild fibrosis
- 10%
- Moderate fibrosis
- 4%
- Severe fibrosis
- 0
BMD abnormalities in SS
- Osteopenia
- 30%
- Osteoporosis
- 60%
Original publication
Clinical Characteristics, and Prevalence of Hepatic and Bone Mineral Density Abnormalities in Patients With Sheehan Syndrome: Data From a Tertiary Care Center. Endocr Pract. Published 17 December 2024. doi:10.
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