Predicting type 2 diabetes and testosterone effects in high-risk Australian men: development and external validation of a 2-year risk model
Authors' conclusion
Baseline HbA1c and 2-h OGTT glucose predict incident type 2 diabetes at 2 years in high-risk men, with risk modified independently by testosterone treatment. Men with HbA1c ≥ 5.6% (38 mmol/mol) benefit most from testosterone treatment, beyond a lifestyle program.
Study context
- Population
- Men aged 50 years+ at high risk of T2D (impaired glucose tolerance, not T2D), Australia
- Participants
- 783 vs 236
- Comparison
- Development vs Validation
- Developmentn = 783
- Validationn = 236
- Outcome
- Incident T2D (2-h OGTT glucose ≥11.1 mmol/L)
- Follow-up
- 2 years
Methodological detailssecondary analysis of multicenter 2-year trial of testosterone vs placebo, penalized logistic regression
- Secondary analysis of multicenter 2-year trial of testosterone vs placebo
- Penalized logistic regression
Performance
As reported in the abstract
Discrimination of the final model for incident T2D
Development
0.827
C-statistic
Validation
0.798
C-statistic
- Testosterone × HbA1c interaction (greater benefit with HbA1c ≥ 5.6%, 38 mmol/mol)
- P = 0.035
Original publication
Predicting type 2 diabetes and testosterone effects in high-risk Australian men: development and external validation of a 2-year risk model. Eur J Endocrinol. Published 25 December 2024. doi:10.
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