Prediagnostic Vitamin D Status and Colorectal Cancer Survival by Vitamin D Binding Protein Isoforms in US Cohorts
Authors' conclusion
In these 2 US cohorts, we found that lower 25(OH)D levels were associated with higher overall mortality, but this association did not differ by Gc isoforms.
Study context
- Population
- Participants with colorectal cancer (CRC) in 2 prospective US cohorts, followed until death or last follow-up (2018)
- Participants
- 588 participants
- Exposure
- Deficient vs sufficient prediagnostic 25D concentrations, by Gc isoform
- Outcome
- Overall and CRC-specific mortality by prediagnostic 25(OH)D, according to vitamin D binding protein (Gc) isoforms
Methodological details2 prospective US cohorts, Cox proportional hazards regression
- 2 prospective US cohorts
- Cox proportional hazards regression
Main finding
As reported in the abstract
Overall mortality, deficient vs sufficient 25(OH)D, by Gc isoform
Deficient vs SufficientHazard ratio (95% CI)P value
Gc1-1 isoform (rs4588 CC)
2.43(1.26–4.70)
Gc1-2 or Gc2-2 isoform (rs4588 CA or AA)
1.63(0.88–3.02)
P = 0.54for interactionObservational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CRC-specific mortality, deficient vs sufficient 25(OH)D, by Gc isoformDeficientvs SufficientGc1-1 isoform | 1.18 (0.27–5.14) | ||
| CRC-specific mortality, deficient vs sufficient 25(OH)D, by Gc isoformDeficientvs SufficientGc1-2 or Gc2-2 isoform | 1.41 (0.62–3.24) | P for interaction = 0.94 | |
| Overall mortality, all participants | 2.06 (1.34–3.18) | ||
| CRC-specific mortality, all participants | 1.51 (0.75–3.07) | ||
| 0.20.5125Hazard ratio (log scale) |
Original publication
Prediagnostic Vitamin D Status and Colorectal Cancer Survival by Vitamin D Binding Protein Isoforms in US Cohorts. J Clin Endocrinol Metab. Published 23 December 2022. doi:10.
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